Wikipedia.
- Jimmy "Two-Teeth"
- The rat that lives and runs various shady businesses out of his hole in Sam and Max's office. He could not care less that Sam and Max don't like him living there; in fact, he considers them to be the pest problem. He always avoids getting involved in their business and vice versa. Jimmy is married and has a child named Timmy, whose only issue is his "terminal Tourette's."
- Bosco
- Bosco owns and runs "Bosco's Inconvenience," a small store at the end of the Sam & Max's block. Bosco is extremely paranoid about everyone and everything, although he places a certain degree of trust in Sam and Max. He therefore takes great care to keep his store secure. He is also the inventor of a line of "Boscotech" products that he sells at extravagant prices, though these items are just useful applications of everyday items. (His million-dollar "voice modulator", for instance, consists of a helium balloon on the end of an inhaler.) He regularly disguises himself to avoid detection from the many authorities he claims are "out to get him." These disguises are varied, though highly transparent (he even leaves his name tag on) and his unconvincing fake accents (which he often forgets to use) fool nobody. In the fourth episode of Season One, it is revealed that his paranoia has just cause; he is in fact targeted by the government.
- During the game the player can ask Bosco to supply Sam and Max with various items. These objects are inventory items in other games, including Hit the Road, The Secret of Monkey Island, and others.
- Sybil Pandemik
- The owner of the store on the corner across from Sam and Max's office. A "short attention spanned careerist", Sybil changes professions with alarming frequency. Her more recent jobs include interior decorator, taxidermist, tattooist, psychotherapist, tabloid journalist, professional witness, dating service, carbon-dating service, beta tester, and Queen of Canada. She has changed occupation in each episode, though her parlor still retains obsolete mementos from previous months. Her name is a play on the phrase "civil pandemic."
- The Soda Poppers
- Three ex-child stars from the 1970s TV series of the same name, the vertically-challenged (Apparently from too much caffeine.) triplets Whizzer, Peepers, and Specs are still familiar icons in the modern world. In Abe Lincoln Must Die!, they were elected as the governors of West, North, and South Dakota respectively, and then declared civil war on each other.
- Hugh Bliss
- An eerily cheerful magician who is trying to sell books on "Prismatology", his feel-good self-help system based on the colors of the rainbow. He can perform many astounding magic tricks, including changing his appearance, disappearing, and mind reading. Sam has an intense distrust of Hugh and considers him to be a quack, but Max adores him to the point of obsession and eventually becomes a fan of Prismatology. Hugh is revealed in Episode 6 to be the one that has been trying to hypnotize everyone for his own nefarious plans. He was also revealed to be a form of cosmic bacteria that feeds on peoples' endorphins, regardless of whether it is of their own free will or not. After his defeat in Episode 6, Hugh Bliss begins to work for Satan. He is put in charge of the FCC, making sure that he bleeps out anyone who swears.
